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Article

Rare HRAS alleles and susceptibility to human breast cancer.

Genomics - 1 Jan 1990

Hall J M, Huey B, Morrow J, Newman B, Lee M, Jones E, Carter C, Buehring G C, King M C

Abstract excerpt

The suggestion that inherited rare alleles at the HRAS oncogene locus might be associated with susceptibility to breast cancer led us to test linkage of HRAS and the neighboring region of 11p15 to breast cancer susceptibility in 12 high-risk families. Linkage could be excluded within 17 cM of HRAS; the lod score for close linkage to HRAS was -19.9. In addition, rare HRAS alleles segregated independently of breast...

Topics

Alleles
Breast Neoplasms
Gene Frequency
Genes, ras
Genetic Linkage
Humans
Lod Score
Pedigree

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2406196
DOI: 10.1016/0888-7543(90)90466-8

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2406196-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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