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Article

ALK in lung cancer: past, present, and future.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2013

Shaw Alice T, Engelman Jeffrey A

Abstract excerpt

In 2007, scientists discovered that anaplastic lymphoma kinase (ALK) gene rearrangements are present in a small subset of non-small-cell lung cancers. ALK-positive cancers are highly sensitive to small-molecule ALK kinase inhibitors, such as crizotinib. Phase I and II studies of crizotinib in ALK-positive lung cancer demonstrated impressive activity and clinical benefit, leading to rapid US Food and Drug...

Topics

Anaplastic Lymphoma Kinase
Carcinoma, Non-Small-Cell Lung
Clinical Trials as Topic
Crizotinib
Drug Resistance, Neoplasm
Gene Rearrangement
Humans
Lung Neoplasms
Mutation
Protein Kinase Inhibitors
Pyrazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyridines

Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 23401436
DOI: 10.1200/JCO.2012.44.5353
PMCID: PMC4209068

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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