Mapping of the binding landscape for a picomolar protein-protein complex through computation and experiment.

Abstract excerpt

Our understanding of protein evolution would greatly benefit from mapping of binding landscapes, i.e., changes in protein-protein binding affinity due to all single mutations. However, experimental generation of such landscapes is a tedious task due to a large number of possible mutations. Here, we use a simple computational protocol to map the binding landscape for two homologous high-affinity complexes,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acetylcholinesterase
• Share to Cholinesterase Inhibitors