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Article

Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.

Protein engineering, design & selection : PEDS - 1 Oct 2009

Sharabi Oz, Peleg Yoav, Mashiach Efrat, Vardy Eyal, Ashani Yacov, Silman Israel, Sussman Joel L, Shifman Julia M

Abstract excerpt

Predicting mutations that enhance protein-protein affinity remains a challenging task, especially for high-affinity complexes. To test our capability to improve the affinity of such complexes, we studied interaction of acetylcholinesterase with the snake toxin, fasciculin. Using the program ORBIT...

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Identifiers

PMID: 19643977
DOI: 10.1093/protein/gzp045
PMCID: PMC2742391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19643977-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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