Article
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
PloS one - 1 Jan 2013
Bhatnagar Pallav, Barron-Casella Emily, Bean Christopher J, Milton Jacqueline N, Baldwin Clinton T, Steinberg Martin H, Debaun Michael, Casella James F, Arking Dan E
Abstract excerpt
In pediatric sickle cell disease (SCD) patients, it has been reported that higher systolic blood pressure (SBP) is associated with increased risk of a silent cerebral infarction (SCI). SCI is a major cause of neurologic morbidity in children with SCD, and blood pressure is a potential modulator of clinical manifestations of SCD; however, the risk factors underlying these complications are not well characterized....
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