Article
Polymorphism of catalase gene promoter in Romanian patients with diabetic kidney disease and type 1 diabetes.
Romanian journal of internal medicine = Revue roumaine de medecine interne - 1 Jan 2010
Panduru N M, Moţa E, Moţa Maria, Cimponeriu D, Serafinceanu C, Cheţa D M
Abstract excerpt
Hyperglycaemia leads to ROS (Reactive oxygen species) generation, affecting the cells that cannot decrease glucose uptake such as: glomerular epithelial cells, mesangial cells and proximal tubule cells. ROS excess seems to activate important pathogenic pathways of development of diabetic nephropathy. The decrease of CAT activity, one of the most important antioxidant enzymes, following to some genetic defects,...
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