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“Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia’’

20 Sept 2013

Abstract excerpt

Despite significant progress in treatment, chronic lymphocytic leukemia (CLL) remains an incurable disease. Advances have been made to understand the molecular pathogenesis underlying CLL progression and treatment resistance. We here review the available evidences concerning the role of the B-cell receptor (BCR) and the tumor microenvironment interactions in CLL pathogenesis. Antigen likely has a key role in the...

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PMID: 24056719
DOI: 10.1038/bcj.2013.45

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