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Unraveling the Bone Tissue Microenvironment in Chronic Lymphocytic Leukemia

19 Oct 2023

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western countries. Although characterized by the progressive expansion and accumulation of leukemic B cells in peripheral blood, CLL cells develop in protective niches mainly located within lymph nodes and bone marrow. Multiple interactions between CLL and microenvironmental cells may favor the expansion of a B cell clone, further driving immune...

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PMID: 37894425
DOI: 10.3390/cancers15205058

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