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Article

In silico study on multidrug resistance conferred by I223R/H275Y double mutant neuraminidase.

Molecular bioSystems - 1 Nov 2013

Tan Hua, Wei Kun, Bao Jiguang, Zhou Xiaobo

Abstract excerpt

It was recently reported that an I223R/H275Y double mutant of neuraminidase (NA) creates a multidrug-resistant form of the pandemic influenza A (H1N1) virus. However, a comprehensive understanding of the molecular mechanisms is still lacking. We conducted a systematic in silico study to explore the structural basis underlying this multidrug resistance. By molecular docking analyses and molecular dynamics (MD)...

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Source

Identifiers

PMID: 24056678
DOI: 10.1039/c3mb70253g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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