Article
Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.
Journal of virology - 1 Dec 2016
Wu Yan, Gao Feng, Qi Jianxun, Bi Yuhai, Fu Lifeng, Mohan Sankar, Chen Yuhang, Li Xuebing, Pinto B Mario, Vavricka Christopher J, Tien Po, Gao George F
Abstract excerpt
Influenza virus neuraminidase (NA) drug resistance is one of the challenges to preparedness against epidemic and pandemic influenza virus infections. NA N1- and N2-containing influenza viruses are the primary cause of seasonal epidemics and past pandemics. The structural and functional basis underlying drug resistance of the influenza virus N1 NA is well characterized. Yet drug resistance of the N2 strain is not...
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