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The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast.

Biochimica et biophysica acta - 1 Dec 2013

Horowitz Avital, Lapointe Jason F, Eid Rawan, Sheibani Sara, Gharib Nada, Jones Natalie K, Vali Hojatollah, Mandato Craig A, Greenwood Michael T

Abstract excerpt

The mechanisms of programmed cell death activate genetically encoded intracellular programs in a controlled manner, the most common form being apoptosis. Apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated by the oligomerization of Bax, a cardinal regulator of mitochondrial-mediated apoptosis. Heterologous expression of Bax in yeast causes cell death that shares a number...

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PMID: 24055994
DOI: 10.1016/j.bbamcr.2013.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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