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Article

TCTP protects from apoptotic cell death by antagonizing bax function.

Cell death and differentiation - 1 Aug 2008

Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson A R, Busso D, Poussin P, Marine J-C, Martinou J-C, Cavarelli J, Moras D, Amson R, Telerman A

Abstract excerpt

Translationally controlled tumor protein (TCTP) is a potential target for cancer therapy. It functions as a growth regulating protein implicated in the TSC1-TSC2 -mTOR pathway or a guanine nucleotide dissociation inhibitor for the elongation factors EF1A and EF1Bbeta. Accumulating evidence indica...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18274553
DOI: 10.1038/cdd.2008.18

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18274553-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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TCTP protects from apoptotic cell death by antagonizing bax function.PMID 18274553Read ↗

Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP.Semantic proximity Read ↗

Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer CellsSemantic proximity Read ↗

TCTP is Essential for Cell Proliferation and Survival during CNS Development.Semantic proximity Read ↗

Structure-function relationship in the tocopherol transfer protein.Semantic proximity Read ↗

TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathwaySemantic proximity Read ↗

Differential regulation of BAX and BAK apoptotic activity revealed by a novel small moleculeSemantic proximity Read ↗

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core.Semantic proximity Read ↗

The translationally controlled tumour protein (TCTP)Semantic proximity Read ↗

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.Semantic proximity Read ↗

A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.Semantic proximity Read ↗

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read ↗

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