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Article

The actin cytoskeleton, RAS-cAMP signaling and mitochondrial ROS in yeast apoptosis.

Trends in cell biology - 1 Dec 2005

Breitenbach Michael, Laun Peter, Gimona Mario

Abstract excerpt

The release of reactive oxygen species (ROS) by mitochondria instigates the pathways of programmed cell death in eukaryotic cells. Gourlay and Ayscough present intriguing experimental evidence that mutations in the genes encoding the regulatory proteins End3p and Sla1p, which influence actin dynamics in budding yeast, lead to a loss of mitochondrial membrane potential, resulting in ROS production and apoptosis....

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Identifiers

PMID: 16226888
DOI: 10.1016/j.tcb.2005.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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