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Article

Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.

Gastroenterology - 1 Jan 2014

Ikeda Atsuyuki, Shimizu Takahiro, Matsumoto Yuko, Fujii Yosuke, Eso Yuji, Inuzuka Tadashi, Mizuguchi Aya, Shimizu Kazuharu, Hatano Etsuro, Uemoto Shinji, Chiba Tsutomu, Marusawa Hiroyuki

Abstract excerpt

BACKGROUND & AIMS: Hepatocellular carcinoma develops in patients with chronic hepatitis or cirrhosis via a stepwise accumulation of various genetic alterations. To explore the genetic basis of development of hepatocellular carcinoma in hepatitis C virus (HCV)-associated chronic liver disease, we evaluated genetic variants that accumulate in nontumor cirrhotic liver. METHODS: We determined the whole exome...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

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Share to Liver Neoplasms, Experimental

Share to Receptors, Leptin

Source

Identifiers

PMID: 24055508
DOI: 10.1053/j.gastro.2013.09.025

Genes

LEPR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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