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Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

19 Aug 2010

Abstract excerpt

BACKGROUND: Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its receptors in HCC and the correlation between leptin and human telomerase reverse transcriptase (hTERT), a known mediator of cellular immortalization. METHODS: We...

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PMID: 20723213
DOI: 10.1186/1471-2407-10-442

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