Article
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.
Immunity - 19 Sept 2013
Brain Oliver, Owens Benjamin M J, Pichulik Tica, Allan Philip, Khatamzas Elham, Leslie Alasdair, Steevels Tessa, Sharma Sameer, Mayer Alice, Catuneanu Ana Maria, Morton Victoria, Sun Mei-Yi, Jewell Derek, Coccia Margherita, Harrison Oliver, Maloy Kevin, Schönefeldt Susann, Bornschein Simon, Liston Adrian, Simmons Alison
Abstract excerpt
NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of microRNAs (miRNAs). miR-29 expression was upregulated in human dendritic cells (DCs) in response to NOD2 signals, and miR-29 regulated the expression of multiple immune mediators. In particular, miR-29 downregulated interleukin-23 (IL-23) by targeting...
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