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Article

MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis

1 Jan 2015

Abstract excerpt

BACKGROUND: MicroRNA-19a (miR-19a), an oncogenic microRNA, has been recently reported to target CD22 in B cell lymphoma cell lines, but its role in inflammatory response is unclear. CD22 is a negative regulator for BCR signaling, and we hypothesize that miR-19a regulates B cell response by targeting CD22 in sepsis. MATERIAL AND METHODS: In order to determine whether miR-19a-CD22 pathway was involved in sepsis,...

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PMID: 26017478
DOI: 10.12659/msm.894321

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