Article
Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes.
BMC medical genetics - 20 Sept 2013
da Silva Andréa Lúcia Gonçalves, da Rosa Helen Tais, Karnopp Thaís Evelyn, Charlier Clara Forrer, Ellwanger Joel Henrique, Moura Dinara Jaqueline, Possuelo Lia Gonçalves, Valim Andréia Rosane de Moura, Guecheva Temenouga Nikolova, Henriques João Antonio Pêgas
Abstract excerpt
BACKGROUND: We investigated a potential link between genetic polymorphisms in genes XRCC1 (Arg399Gln), OGG1 (Ser326Cys), XRCC3 (Thr241Met), and XRCC4 (Ile401Thr) with the level of DNA damage and repair, accessed by comet and micronucleus test, in 51 COPD patients and 51 controls. METHODS: Peripheral blood was used to perform the alkaline and neutral comet assay; and genetic polymorphisms by PCR/RFLP. To assess...
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