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Article

Mutations and polymorphisms in FSH receptor: functional implications in human reproduction.

Reproduction (Cambridge, England) - 1 Dec 2013

Desai Swapna S, Roy Binita Sur, Mahale Smita D

Abstract excerpt

FSH brings about its physiological actions by activating a specific receptor located on target cells. Normal functioning of the FSH receptor (FSHR) is crucial for follicular development and estradiol production in females and for the regulation of Sertoli cell function and spermatogenesis in males. In the last two decades, the number of inactivating and activating mutations, single nucleotide polymorphisms, and...

Topics

Animals
Female
Humans
Infertility
Male
Models, Molecular
Mutation
Polymorphism, Genetic
Receptors, FSH
Reproduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24051057
DOI: 10.1530/REP-13-0351

Genes

FSHR

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