Functional and clinical consequences of mutations in the FSH receptor.

doi:10.1016/s0303-7207(96)03949-4

Back to search

Article

Functional and clinical consequences of mutations in the FSH receptor.

Molecular and cellular endocrinology - 20 Dec 1996

Gromoll J, Simoni M, Nordhoff V, Behre H M, De Geyter C, Nieschlag E

Abstract excerpt

The follicle-stimulating hormone (FSH) is essential for normal gametogenesis. In females FSH is required for ovarian development and follicle maturation whereas in males FSH determines Sertoli cell number and quantitatively and qualitatively normal spermatogenesis. FSH action is mediated by a G-p...

Topics

Amino Acid Sequence
Animals
Base Sequence
Female
Glycosylation
Humans
Male
Mutation
Receptors, FSH

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.