Article
Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma.
Japanese journal of clinical oncology - 1 Dec 2013
Zeng Lu, You Gyokukou, Tanaka Hideaki, Srivatanakul Petcharin, Ohta Emi, Viwatthanasittiphong Chutiwan, Matharit Mantana, Chenvidhya Dhiraphol, Jedpiyawongse Adisorn, Tanaka Masakazu, Fujii Takahiro, Sripa Banchob, Ohshima Kazuhiko, Miwa Masanao, Honjo Satoshi
Abstract excerpt
OBJECTIVE: Although Opisthorchis viverrini is a risk factor for cholangiocarcinoma, not all the infected individuals develop cholangiocarcinoma. We investigated whether the base excision repair enzyme gene polymorphisms with differentiated repair capacities of inflammation-related deoxyribonucleic acid damage may play a key role and such possible effects from those genes may be increased or diminished in...
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