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Article

Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome.

Cerebral cortex (New York, N.Y. : 1991) - 1 Feb 2015

Lauterborn Julie C, Jafari Matiar, Babayan Alex H, Gall Christine M

Abstract excerpt

Fragile X Syndrome (FXS) and the Fmr1 knockout (KO) mouse model of this disorder exhibit abnormal dendritic spines in neocortex, but the degree of spine disturbances in hippocampus is not clear. The present studies tested if the mutation influences dendritic branching and spine measures for CA1 pyramidal cells in Fmr1 KO and wild-type (WT) mice provided standard or enriched environment (EE) housing. Automated...

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Source

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Identifiers

PMID: 24046080
DOI: 10.1093/cercor/bht249
PMCID: PMC4303803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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