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Article

Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

13 Sept 2013

Abstract excerpt

Axonal degeneration in peripheral nerves after injury is accompanied by myelin degradation initiated by Schwann cells (SCs). These cells activate autophagy, a ubiquitous cytoprotective process essential for degradation and recycling of cellular constituents. Concomitantly to nerve insult and axonal degeneration, neuropathic pain (NeP) arises. The role of SC autophagy in the mechanisms underlying NeP is still...

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PMID: 24041962
DOI: 10.1016/j.pain.2013.09.013

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