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Article

Ion channel gene expression in human lung, skin, and cord blood-derived mast cells.

Journal of leukocyte biology - 1 May 2003

Bradding Peter, Okayama Yoshimichi, Kambe Naotomo, Saito Hirohisa

Abstract excerpt

Immunoglobulin E (IgE)-dependent activation of human mast cells (HMC) is characterized by an influx of extracellular calcium (Ca(2+)), which is essential for subsequent release of preformed (granule-derived) mediators and newly generated autacoids and cytokines. In addition, flow of ions such as K(+) and Cl(-) is likely to play an important role in mast cell activation, proliferation, and chemotaxis through their...

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Identifiers

PMID: 12714576
DOI: 10.1189/jlb.1202602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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