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Article

Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08.

PloS one - 1 Jan 2013

Shrestha Sanjib, Grilley Michelle, Fosso Marina Y, Chang Cheng-Wei T, Takemoto Jon Y

Abstract excerpt

A novel aminoglycoside, FG08, that differs from kanamycin B only by a C8 alkyl chain at the 4″-O position, was previously reported. Unlike kanamycin B, FG08 shows broad-spectrum fungicidal but not anti-bacterial activities. To understand its specificity for fungi, the mechanism of action of FG08 was studied using intact cells of the yeast Saccharomyces cerevisiae and small unilamellar membrane vesicles. With...

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Identifiers

PMID: 24040088
DOI: 10.1371/journal.pone.0073843
PMCID: PMC3769384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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