Article
Osmotin, a plant antifungal protein, subverts signal transduction to enhance fungal cell susceptibility.
Molecular cell - 1 May 1998
Yun D J, Ibeas J I, Lee H, Coca M A, Narasimhan M L, Uesono Y, Hasegawa P M, Pardo J M, Bressan R A
Abstract excerpt
The plant pathogenesis-related protein osmotin is an antifungal cytotoxic agent that causes rapid cell death in the yeast S. cerevisiae. We show here that osmotin uses a signal transduction pathway to weaken defensive cell wall barriers and increase its cytotoxic efficacy. The pathway activated b...
Topics
- Antifungal Agents
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Death
- Cell Wall
- Cytotoxins
- Drug Resistance, Microbial
- Fungal Proteins
- GTPase-Activating Proteins
- Lipoproteins
- Morphogenesis
- Mutation
- Pheromones
- Plant Proteins
- Plants, Toxic
- Saccharomyces cerevisiae