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Article

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop

25 Nov 2014

Abstract excerpt

BACKGROUND: The effective mechanisms of microRNAs (miRNAs) functions as oncogenes or tumour suppressors in human hepatocellular carcinoma (HCC) are still obscure. Here, we investigated the function and expression of miR-1228 in HCC. METHODS: The role of miR-1228 in HCC was determined by colony formation, transwell, and nude mice xenograft experiments. miR-1228 target gene were identified by EGFP reporter assays,...

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PMID: 25422913
DOI: 10.1038/bjc.2014.593

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