Back to search

Article

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

2023-07-02

Abstract excerpt

MicroRNA miR-122 plays a pivotal role in liver function. Despite numerous studies investigating this miRNA, the global network of genes regulated by miR-122 and its contribution to the underlying pathophysiological mechanisms remain largely unknown. To gain a deeper understanding of miR-122 activity, we employed two complementary approaches. Firstly, through transcriptome analysis of polyribosome-bound RNAs, we di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ebf5a02f-b14a-532f-b6e6-04b3c53d2c9d
DOI
10.1101/2023.06.30.547158
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signalingDOI 10.1101/2023.06.30.547158
Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C.Semantic proximity
Antiviral therapy reduces hepatocellular carcinoma through suppressing hepatitis B virus replication may improve ER stress, mitochondrial and metabolic dysfunctions and decrease p62 in hybridized mice with single HBV transgene and miR‐122Semantic proximity
Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patientsSemantic proximity
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activitySemantic proximity
Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122Semantic proximity
Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesisSemantic proximity
MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent ReplicationSemantic proximity
Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levelsSemantic proximity
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.Semantic proximity
microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV InfectionSemantic proximity
The liver‐specific microRNA‐122*, the complementary strand of microRNA‐122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitrySemantic proximity
Hepatitis C virus' Achilles' heel--dependence on liver-specific microRNA miR-122.Semantic proximity
Select a neighboring publication to make it the new centre.