Article
Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort.
International journal of cancer - 15 Mar 2014
Rinaldi S, Biessy C, Hernandez M, Lesueur F, dos-Santos-Silva I, Rice M S, Lajous M, Lopez-Ridaura R, Torres-Mejía G, Romieu I
Abstract excerpt
The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We...
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