Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization.

doi:10.1007/s10549-024-07306-w

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Article

Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization.

Breast cancer research and treatment - 1 Jul 2024

Haas Cameron B, Chen Hongjie, Harrison Tabitha, Fan Shaoqi, Gago-Dominguez Manuela, Castelao Jose E, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Dunning Alison M, Easton Douglas F, Antoniou Antonis C, Hall Per, Czene Kamila, Andrulis Irene L, Mulligan Anna Marie, Milne Roger L, Fasching Peter A, Haeberle Lothar, Garcia-Closas Montserrat, Ahearn Thomas, Gierach Gretchen L, Haiman Christopher, Maskarinec Gertraud, Couch Fergus J, Olson Janet E, John Esther M, Chenevix-Trench Geogia, Berrington de Gonzalez Amy, Jones Michael, Stone Jennifer, Murphy Rachel, Aronson Kristan J, Wernli Karen J, Hsu Li, Vachon Celine, Tamimi Rulla M, Lindström Sara

Abstract excerpt

PURPOSE: Mammographic density phenotypes, adjusted for age and body mass index (BMI), are strong predictors of breast cancer risk. BMI is associated with mammographic density measures, but the role of circulating sex hormone concentrations is less clear. We investigated the relationship between BMI, circulating sex hormone concentrations, and mammographic density phenotypes using Mendelian randomization (MR)....

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Identifiers

PMID: 38653906
DOI: 10.1007/s10549-024-07306-w
PMCID: PMC12851615

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SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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