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Article

Attenuation of Plasmodium falciparum in vitro drug resistance phenotype following culture adaptation compared to fresh clinical isolates in Cambodia.

Malaria journal - 2 Dec 2015

Chaorattanakawee Suwanna, Lanteri Charlotte A, Sundrakes Siratchana, Yingyuen Kritsanai, Gosi Panita, Chanarat Nitima, Wongarunkochakorn Saowaluk, Buathong Nillawan, Chann Soklyda, Kuntawunginn Worachet, Arsanok Montri, Lin Jessica T, Juliano Jonathan J, Tyner Stuart D, Char Mengchuor, Lon Chanthap, Saunders David L

Abstract excerpt

BACKGROUND: There is currently no standardized approach for assessing in vitro anti-malarial drug susceptibility. Potential alterations in drug susceptibility results between fresh immediate ex vivo (IEV) and cryopreserved culture-adapted (CCA) Plasmodium falciparum isolates, as well as changes in parasite genotype during culture adaptation were investigated. METHODS: The 50 % inhibitory concentration (IC50) of...

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Identifiers

PMID: 26626127
DOI: 10.1186/s12936-015-1021-8
PMCID: PMC4667454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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