Article
Stages of T-cell receptor protein expression in T-cell acute lymphoblastic leukemia.
Blood - 1 Apr 1991
Campana D, van Dongen J J, Mehta A, Coustan-Smith E, Wolvers-Tettero I L, Ganeshaguru K, Janossy G
Abstract excerpt
In this study five monoclonal antibodies (MoAbs) to T-cell receptor (TCR) proteins (WT31, alpha F1, beta F1, TCR delta-1 and delta TCS-1) were used to identify discrete maturative stages in 40 cases of T-cell acute lymphoblastic leukemia (T-ALL). These MoAbs reacted exclusively with CD3+ T cells and did not label B-lineage and myeloid cells. In 17 of the 40 T-ALL cases studied the leukemic blasts lacked membrane...
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