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Article

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

26 Oct 2021

Abstract excerpt

The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes. Given that there is no effective way to directly inhibit c-Myc, c-Myc targeting strategies hold great potential for cancer therapy. In this study, we found that WSB1, which has a highly...

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PMID: 35530152
DOI: 10.1016/j.apsb.2021.10.021

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