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Article

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.

Development (Cambridge, England) - 1 Apr 1995

Xu T, Wang W, Zhang S, Stewart R A, Yu W

Abstract excerpt

We have identified recessive overproliferation mutations by screening and examining clones of mutant cells in genetic mosaics of the fruitfly Drosophila melanogaster. This type of screen provides a powerful approach for identifying and studying potential tumor suppressors. One of the identified genes, lats, has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with...

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Identifiers

PMID: 7743921
DOI: 10.1242/dev.121.4.1053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.PMID 7743921Read ↗

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Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.Semantic proximity Read ↗

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.Semantic proximity Read ↗

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomasSemantic proximity Read ↗

The role of lats in cell cycle regulation and tumorigenesis.Semantic proximity Read ↗

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.Semantic proximity Read ↗

Induction of epithelial tumors in Drosophila melanogaster heterozygous for the tumor suppressor gene wts.Semantic proximity Read ↗

Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.Semantic proximity Read ↗

minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation.Semantic proximity Read ↗

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