Article
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.
Development (Cambridge, England) - 1 Apr 1995
Xu T, Wang W, Zhang S, Stewart R A, Yu W
Abstract excerpt
We have identified recessive overproliferation mutations by screening and examining clones of mutant cells in genetic mosaics of the fruitfly Drosophila melanogaster. This type of screen provides a powerful approach for identifying and studying potential tumor suppressors. One of the identified g...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Cycle
- Cell Division
- Cloning, Molecular
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Insect
- Genes, Tumor Suppressor
- Molecular Sequence Data
- Mosaicism
- Neurospora
- Phenotype
- Protein Kinases
- Sequence Analysis, DNA
- Yeasts