Non-canonical p53 signaling to promote invasion.

Abstract excerpt

It has been known for a number of years that mutated "inactive" p53 proteins still capable of binding to DNA per se, can bind to DNA sequences that are non-canonical for p53, with for example, a resultant increase in the transcription and expression of growth factor receptors such as ERBB1, (1)(,) (2) i.e., mutation of p53 not merely results in "no p53 function" but in fact results in "oncogenic p53 function"....

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