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Article

How does parkin ligate ubiquitin to Parkinson's disease?

EMBO reports - 1 Jul 2004

Kahle Philipp J, Haass Christian

Abstract excerpt

Recessive mutations in the human PARKIN gene are the most common cause of hereditary parkinsonism, which arises from the degeneration of dopaminergic neurons in the substantia nigra. However, the molecular mechanisms by which the loss of parkin causes dopaminergic neurodegeneration are not well understood. Parkin is an enzyme that ubiquitinates several candidate substrate proteins and thereby targets them for...

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Identifiers

PMID: 15229644
DOI: 10.1038/sj.embor.7400188
PMCID: PMC1299099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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