Article
Parkin directly modulates 26S proteasome activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2010
Um Ji Won, Im Eunju, Lee Hyun Jung, Min Boram, Yoo Lang, Yoo Jiho, Lübbert Hermann, Stichel-Gunkel Christine, Cho Hyun-Soo, Yoon Jong Bok, Chung Kwang Chul
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains poorly understood, recent genetic, postmortem, and experimental evidence shows that abnormal protein accumulation and subsequent aggregate formation are prominent features of both sporadic and familial PD. While proteasome...
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