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Article

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease

14 Dec 2011

Abstract excerpt

Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzheimer's disease pathology. However, given that age is the greatest risk factor for AD, we explored an alternative drug discovery scheme that is based upon efficacy in...

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PMID: 22194796
DOI: 10.1371/journal.pone.0027865

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