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Article

Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.

Blood - 17 Oct 2013

Zhang Yi, Owens Kristina, Hatem Layla, Glass Carolyn H, Karuppaiah Kannan, Camargo Fernando, Perkins Archibald S

Abstract excerpt

A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) including MLL-AF9 activates the Mecom locus and exhibits extremely poor clinical prognosis. Mecom encodes EVI1 and MDS1-EVI1 (ME) proteins via alternative transcription start sites; these differ by the presence of a PR...

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Share to Cell Lineage
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Mice, Knockout

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

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Source

Open in PubMed Open full text

Identifiers

PMID: 24021671
DOI: 10.1182/blood-2012-08-453662
PMCID: PMC3799001

Genes

HOXA9
MEIS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24021671-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.PMID 24021671Read ↗

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