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Article

Cause-specific telomere factors deregulation in hepatocellular carcinoma

11 Sept 2013

Abstract excerpt

BACKGROUND: Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. Telomeres, the chromosome extremities, are protected by specific proteins, the shelterin complex and by additional factors. Besides telomerase dysregulation, expression changes of these telomere factors have been observed in cancers. METHODS:...

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PMID: 24020493
DOI: 10.1186/1756-9966-32-64

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