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Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target

16 Dec 2020

Abstract excerpt

BACKGROUND & AIMS: Telomerase activation is the earliest event in hepatocellular carcinoma (HCC) development. Thus, we aimed to elucidate the role of telomere length maintenance during liver carcinogenesis. METHODS: Telomere length was measured in the tumor and non-tumor liver tissues of 1,502 patients (978 with HCC) and integrated with TERT alterations and expression, as well as clinical and molecular (analyzed...

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PMID: 33338512
DOI: 10.1016/j.jhep.2020.11.052

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