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The Genetic Variant TNFA (rs361525) Is Associated with Increased Susceptibility to Developing Dengue Symptoms.

Viral immunology - 1 Apr 2023

Villanueva-Aguilar Mónica Edith, Rizo-de-la-Torre Lourdes Del Carmen, Granados-Muñiz María Del Pilar, Montoya-Fuentes Andrea, Montoya-Fuentes Héctor

Abstract excerpt

Dengue virus (DENV) is the causal agent of dengue fever. The symptoms and signs of dengue vary from febrile illness to hemorrhagic syndrome. IFITM3 and TNFA are genes of the innate immune system. Variants IFITM3 (rs12252 T>C) and TNFA (rs1800629 G > A and rs361525 G>A) might alter gene expression and change the course of the disease. Our first objective was to determine whether these variants were associated with...

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PMID: 36730734
DOI: 10.1089/vim.2022.0093

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