Article
MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation.
Circulation research - 25 Oct 2013
Li Pan, Zhu Ni, Yi Bing, Wang Nadan, Chen Ming, You Xiaohua, Zhao Xianxian, Solomides Charalambos C, Qin Yongwen, Sun Jianxin
Abstract excerpt
RATIONALE: Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic smooth muscle cell proliferation. OBJECTIVE: To investigate whether miR-663 plays a role in...
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