Article
GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling.
Molecular neurobiology - 1 Feb 2019
Matias Diana, Dubois Luiz Gustavo, Pontes Bruno, Rosário Luciane, Ferrer Valeria Pereira, Balça-Silva Joana, Fonseca Anna Carolina Carvalho, Macharia Lucy Wanjiku, Romão Luciana, E Spohr Tania Cristina Leite de Sampaio, Chimelli Leila, Filho Paulo Niemeyer, Lopes Maria Celeste, Abreu José Garcia, Lima Flavia Regina Souza, Moura-Neto Vivaldo
Abstract excerpt
Glioblastoma is an extremely aggressive and deadly brain tumor known for its striking cellular heterogeneity and capability to communicate with microenvironment components, such as microglia. Microglia-glioblastoma interaction contributes to an increase in tumor invasiveness, and Wnt signaling pathway is one of the main cascades related to tumor progression through changes in cell migration and invasion. However,...
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