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Article

Adjustment for smoking does not alter the FOXO3A association with longevity.

Age (Dordrecht, Netherlands) - 1 Apr 2014

Däumer Carolin, Flachsbart Friederike, Caliebe Amke, Schreiber Stefan, Nebel Almut, Krawczak Michael

Abstract excerpt

Human longevity is a multifactorial phenotype influenced by both genetic and environmental factors. Despite its heritability of 25-32 %, the genetic background of longevity is as yet largely unexplained. Apart from APOE status, variation in the FOXO3A gene is the only confirmed genetic contributor to survival into old age. On the other hand, FOXO3A activity is known to be downregulated in various cancers, and the...

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Identifiers

PMID: 24014251
DOI: 10.1007/s11357-013-9578-z
PMCID: PMC4039245

Genes

APOE

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