Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population.

doi:10.1007/s00125-013-3047-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population.

Diabetologia - 1 Dec 2013

Kuo Jane Z, Sheu Wayne Huey-Herng, Assimes Themistocles L, Hung Yi-Jen, Absher Devin, Chiu Yen-Feng, Mak Jordan, Wang Jun-Sing, Kwon Soonil, Hsu Chih-Cheng, Goodarzi Mark O, Lee I-Te, Knowles Joshua W, Miller Brittany E, Lee Wen-Jane, Juang Jyh-Ming J, Wang Tzung-Dau, Guo Xiuqing, Taylor Kent D, Chuang Lee-Ming, Hsiung Chao A, Quertermous Thomas, Rotter Jerome I, Chen Yii-Der I

Abstract excerpt

AIMS/HYPOTHESIS: Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. METHODS: A total of 9,335 unrelated Chinese Han individuals, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Glucose

Share to Cyclin-Dependent Kinase 5

Share to Diabetes Mellitus, Type 2

Share to Genotyping Techniques

Share to Insulin

Share to tRNA Methyltransferases

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 24013783
DOI: 10.1007/s00125-013-3047-1
PMCID: PMC3825282

Genes

CDKAL1
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population.PMID 24013783Read ↗

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Semantic proximity Read ↗

Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.Semantic proximity Read ↗

Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study.Semantic proximity Read ↗

Progress in Defining the Genetic Contribution to Type 2 Diabetes in Individuals of East Asian Ancestry.Semantic proximity Read ↗

Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.Semantic proximity Read ↗

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.Semantic proximity Read ↗

Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.Semantic proximity Read ↗

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.Semantic proximity Read ↗

Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Genetic advances of type 2 diabetes in Chinese populations.Semantic proximity Read ↗

Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.Semantic proximity Read ↗

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.