Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.

doi:10.1007/s00125-017-4405-1

Article

Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.

Diabetologia - 1 Dec 2017

Bien Stephanie A, Pankow James S, Haessler Jeffrey, Lu Yinchang, Pankratz Nathan, Rohde Rebecca R, Tamuno Alfred, Carlson Christopher S, Schumacher Fredrick R, Bůžková Petra, Daviglus Martha L, Lim Unhee, Fornage Myriam, Fernandez-Rhodes Lindsay, Avilés-Santa Larissa, Buyske Steven, Gross Myron D, Graff Mariaelisa, Isasi Carmen R, Kuller Lewis H, Manson JoAnn E, Matise Tara C, Prentice Ross L, Wilkens Lynne R, Yoneyama Sachiko, Loos Ruth J F, Hindorff Lucia A, Le Marchand Loic, North Kari E, Haiman Christopher A, Peters Ulrike, Kooperberg Charles

Abstract excerpt

AIMS/HYPOTHESIS: Elevated levels of fasting glucose and fasting insulin in non-diabetic individuals are markers of dysregulation of glucose metabolism and are strong risk factors for type 2 diabetes. Genome-wide association studies have discovered over 50 SNPs associated with these traits. Most of these loci were discovered in European populations and have not been tested in a well-powered multi-ethnic study. We...

Topics

Blood Glucose
Diabetes Mellitus, Type 2
Fasting
Female
Genome-Wide Association Study
Humans
Insulin

Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.

Abstract excerpt

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