Article
Lonidamine: a non-mutagenic antitumor agent.
Carcinogenesis - 1 Sept 1990
Forster R, Campana A, D'Onofrio E, Henderson L, Mosesso P, Scorza Barcellona P
Abstract excerpt
Lonidiamine is a novel indazole-carboxylic acid with antitumour properties; it has been studied for potential mutagenicity in a comprehensive battery of tests. In assays for the induction of gene mutations in prokaryotes (Ames test) and eukaryotes (induction of HPRT mutations in CHO cells), negative results were obtained. There was no evidence of the induction of chromosomal damage in cultured mammalian cells in...
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