Article
Lonidamine: a non-mutagenic antitumor agent.
Carcinogenesis - 1 Sept 1990
Forster R, Campana A, D'Onofrio E, Henderson L, Mosesso P, Scorza Barcellona P
Abstract excerpt
Lonidiamine is a novel indazole-carboxylic acid with antitumour properties; it has been studied for potential mutagenicity in a comprehensive battery of tests. In assays for the induction of gene mutations in prokaryotes (Ames test) and eukaryotes (induction of HPRT mutations in CHO cells), negat...
Topics
- Animals
- Antineoplastic Agents
- Biotransformation
- Cell Line
- Chromosome Aberrations
- Female
- Genes, Dominant
- Genes, Lethal
- Hypoxanthine Phosphoribosyltransferase
- Indazoles
- Male
- Mice
- Micronucleus Tests
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Pyrazoles