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Article

Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells

11 Nov 1992

Abstract excerpt

The ability of lonidamine, an energolytic derivative of indazole-carboxylic acid, to modulate the cytotoxicity of cisplatin was investigated in human ovarian-cancer cell lines sensitive (A2780) or with experimentally induced resistance (A2780/cp8) to the alkylating agent. A 24-hr post-incubation with 300 microM lonidamine significantly potentiated the activity of a 1-hr cisplatin treatment in both cell lines. In...

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PMID: 1428236
DOI: 10.1002/ijc.2910520524

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