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Article

Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium.

Cell biology international - 1 Jan 1998

Fernandez P, Wilson C, Hoivik D, Safe S H

Abstract excerpt

T47D human breast cancer cells were cultured in estrogen-deficient media for up to 32 months and the resulting cell line (L(hE(-))) exhibited unique phenotypic and genotypic characteristics. Compared to low passage (L) cells, the L(hE(-)) cells exhibited a significantly higher rate of proliferation, unique morphological features, advanced ploidy status and 5- to 10-fold higher levels of the estrogen receptor (ER)...

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Identifiers

PMID: 10452832
DOI: 10.1006/cbir.1998.0303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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